GENERAL CATALOGUE
R1-ICR-5
HY-171658 · 5 mg
MedChemExpress · Cat: HY-171658
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medchemexpress.com/r1-icr-5.htmlCatalog No: HY-171658
CAS No: 3070346-91-4
Category: Apoptosis
Pack Size: 5 mg
Brand: MedChemExpress
Description
R1-ICR-5 is a selective PROTAC degrader that targets serine/threonine-protein kinase 1 RIPK1 . R1-ICR-5 mediates the degradation of RIPK1 through VHL, thereby deregulating the TNFR1 and TLR3/4 signaling hubs, enhancing the output of NF-?B, MAPK, and IFN signaling, and simultaneously promoting the activation of RIPK3 and the induction of necroptosis. R1-ICR-5 is promising for research of cancers and inflammatory diseases. Pink: PK68 HY-128348 ; Black: linker HY-W012241 ; Blue: S,R,S -AHPC HY-125845 .
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