(Rac)-ACT-451840

Description

Rac -ACT-451840 is an isomer of ACT-451840 that exhibits significant antimalarial effects. Rac -ACT-451840 exhibits significant antimalarial activity against P. berghei-infected mice at a dose of 20 mg/kg ED90=13 mg/kg , and has an inhibitory effect at a dose of 300 mg/kg. The ED90 of Rac -ACT-451840 in the P. falciparum humanized immunodeficient mouse model is 3.7 mg/kg. Rac -ACT-451840 is similar to artemisinin, with a rapid onset of action but requires repeated high doses.