GENERAL CATALOGUE
(Rac)-Upacicalcet
HY-109106B · 5 mg
MedChemExpress · Cat: HY-109106B
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medchemexpress.com/rac-upacicalcet.html
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Catalog No: HY-109106B
CAS No: 2649575-19-7
Category: GPCR G Protein
Pack Size: 5 mg
Brand: MedChemExpress
Description
Rac -Upacicalcet is the racemate of Upacicalcet HY-109106 . Upacicalcet is a non-peptide calcimimetic that acts as a CaSR agonist EC50 = 10.8 nM . Upacicalcet reduces serum intact parathyroid hormone iPTH and serum Ca2+ levels, reducing hypocalcemia and gastrointestinal complications. Upacicalcet improves vascular calcification and bone disorders in the Adenine HY-B0152 -induced secondary hyperparathyroidism SHPT rat model. Upacicalcet inhibits cortical pore formation and reduces bone fibrosis in rats with chronic kidney disease CKD . Upacicalcet is useful for studying SHPT.
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