Raloxifene 4'-glucuronide-d4 lithium

Description

Raloxifene 4-glucuronide-d4 lithium is deuterium labeled Raloxifene 4-glucuronide. Raloxifene 4-glucuronide is a primary metabolite of Raloxifene. Raloxifene 4-glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4-glucuronide binds to estrogen receptor with an IC50 of 370 ?M. . Raloxifene is a selective estrogen receptor modulator. Raloxifene activates TGF?3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression.