Ran-IN-1

Description

Ran-IN-1 Compound M36 is an orally active and selective Ran GTPase inhibitor. Ran-IN-1 binds to the GDP-bound form of Ran RanGDP at the allosteric switch II pocket with high specificity, stabilizing the inactive state and reducing the active Ran-GTP population. Ran-IN-1 induces apoptosis and represses DNA repair pathways like HR and NHEJ in epithelial ovarian cancer EOC cells. Ran-IN-1 is promising for research of EOC, particularly high-grade serous carcinoma.