GENERAL CATALOGUE
RapaLink-1
HY-111373 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-111373
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medchemexpress.com/rapalink-1.htmlCatalog No: HY-111373
CAS No: 1887095-82-0
Category: Autophagy
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
RapaLink-1, the third-generation bivalent mTOR inhibitor, combines Rapamycin HY-10219 with MLN0128 HY-13328, a second-generation mTOR kinase inhibitor by an inert chemical linker. RapaLink-1 shows better efficacy than Rapamycin or mTOR kinase inhibitors TORKi , potently blocking cancer-derived, activating mutants of mTOR. RapaLink-1 can cross the blood-brain barrier. RapaLink-1 binding to FKBP12 results in targeted and durable inhibition of mTORC1. RapaLink-1 plays an antithrombotic role in antiphospholipid syndrome by improving autophagy. Anticancer activity.
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