GENERAL CATALOGUE
Raphin1
HY-123960 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-123960
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Catalog No: HY-123960
CAS No: 2022961-17-5
Category: Metabolic Enzyme Protease
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
Raphin1 is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B R15B . Raphin1 binds strongly to the R15B-PP1c holophosphatase Kd=33 nM , and shows 30-fold selective in binding R15B-PP1c over R15A-PP1c. Raphin1 crosses the blood-brain barrier, and reduces organismal and molecular deficits in a mouse model of a protein misfolding disease.
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