GENERAL CATALOGUE
Razuprotafib
HY-109041 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-109041
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Catalog No: HY-109041
CAS No: 1008510-37-9
Category: Metabolic Enzyme Protease
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
Razuprotafib AKB-9778 is a potent and selective inhibitor of the catalytic activity of VE-PTP vascular endothelial protein tyrosine phosphatase with an IC50of 17 pM. Razuprotafib promotes TIE2 activation, enhances ANG1-induced TIE2 activation, and stimulates phosphorylation of signaling molecules in the TIE2 pathway, including AKT, eNOS, and ERK. Razuprotafib inhibits the structurally related phosphatase PTP1B with an IC50 of 780 nM. Razuprotafib shows excellent selectivity for VE-PTP versus a variety of phosphatases, with the exception of HPTP? IC50=36 pM and HPTP? 100 pM .
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