RC-33 hydrochloride

Description

RC-33 hydrochloride is a selective and metabolically stable ? receptor agonist with activity in enhancing nerve growth factor NGF -induced neurite outgrowth. Both enantiomers of RC-33 hydrochloride bind to the ? receptor with similar affinity and show almost equal effectiveness as ? receptor agonists. The R-configured enantiomer of RC-33 hydrochloride shows higher liver metabolic stability in the presence of NADPH. RC-33 hydrochloride was selected as the best candidate for further in vivo studies in animal models of amyotrophic lateral sclerosis.