RdRP-IN-4

Description

RdRP-IN-4 compound 11q , an aryl benzoyl hydrazide analog, is an orally active influenza A virus RNA-dependent RNA polymerase RdRp inhibitor by interacting with the PB1 subunit. RdRP-IN-4 exhibits potent inhibitory activity against the avian H5N1 flu strain with an EC50 of 18 nM in MDCK cells. RdRP-IN-4 displays excellent potency against the the H1N1 A/PR/8/34 Flu A strain and Flu B strain B/Lee/1940 with EC50 values of 53 nM and 20 nM, respectively. RdRP-IN-4 significantly inhibits the expression level of viral nucleoprotein NP in a dose-dependent manner. RdRP-IN-4 exhibits significant antiviral activity in infected mice.