Recombinant Cynomolgus CRTAM (C-6His)

Description

EnkiLife provides the Recombinant Cynomolgus CRTAM (C-6His) protein,aslo know as Cytotoxic and Regulatory T-Cell Molecule,Class-I MHC-Restricted T-Cell-Associated Molecule,CD355,CRTAM, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Cynomolgus Fascicularis Cytotoxic And Regulatory T-cell Molecule is produced by our Mammalian expression system and the target gene encoding Ser18-Gly287 is expressed with a 6His tag at the C-terminus.Accession:XP_005580021.1. Expression Host:Human Cells.Species:Cynomolgus.Predicted Molecular Mass:30.8 KDa. Background:Cytotoxic and Regulatory T-Cell Molecule (CRTAM) is a member of Nectin family under the immunoglobulin superfamily that is expressed by activated CD8+ and NK T cells. CRTAM is found in spleen, thymus, small intestine, peripheral blood, and it is highly expressed by Purkinje cells of the cerebellum. CRTAM is a type I transmembrane glycoprotein containing one Ig-like C2-type domain and one Ig-like V-type domain in its extracellular domain, while its cytoplasmic region shows a potential class I PDZ domain. CRTAM is expressed as a homodimer on the cell surface but does not show homotypic binding in trans. The high affinity of CRTAM/IGSF4 adhesion allows CRTAM to disrupt IGSF4 homotypic interactions. IGSF4 and T cell receptor coengagement of CD8+ cells expressiong CRTAM induces increased IFNγ or IL-22 production.