Recombinant Human ABCB5 (N-Trx)

Description

EnkiLife provides the Recombinant Human ABCB5 (N-Trx) protein,aslo know as ATP-binding cassette sub-family B member 5,P-glycoprotein ABCB5,ABCB5 P-gp,ABCB5;, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human ATP-binding Cassette Sub-family B Member 5 is produced by our E.coli expression system and the target gene encoding Ile141-Val247 is expressed with a Trx tag at the N-terminus.Accession:Q2M3G0. Expression Host:E.coli.Species:Human.Predicted Molecular Mass:29.4 KDa. Background:ATP-binding cassette sub-family B member 5(ABCB5) is a plasma membrane-spanning protein. ABCB5 is principally expressed in physiological skin and human malignant melanoma. ABCB5 has been suggested to regulate skin progenitor cell fusion and mediate chemotherapeutic drug resistance in stem-like tumor cell subpopulations in human malignant melanoma. It is commonly over-expressed on circulating melanoma tumour cells. Furthermore, the ABCB5+ melanoma- initiating cells were demonstrated to express FLT1 (VEGFR1) receptor tyrosine kinase which was functionally required for efficient xenograft tumor formation, as demonstrated by shRNA knockdown experiments.