Recombinant Human ACE-2 (C-mFc)

Description

EnkiLife provides the Recombinant Human ACE-2 (C-mFc) protein,aslo know as Angiotensin-Converting Enzyme 2,ACE-Related Carboxypeptidase,Angiotensin-Converting Enzyme Homolog,ACEH,Metalloprotease MPROT15,ACE2, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Angiotensin-Converting Enzyme 2 is produced by our Mammalian expression system and the target gene encoding Gln18-Ser740 is expressed with a mouse IgG1 Fc tag at the C-terminus.Accession:Q9BYF1. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:110 KDa. Background:Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.