Recombinant Human Acrp30 (C-6His)

Description

EnkiLife provides the Recombinant Human Acrp30 (C-6His) protein,aslo know as Adiponectin,30 kDa Adipocyte Complement-Related Protein,Adipocyte complement-related 30 kDa protein,ACRP30,Adipocyte,C1q and Collagen Domain-Containing Protein,Adipose Most Abundant Gene Transcript 1 Protein,apM-1,Gelatin-Binding Protein,ADIPOQ,ACDC,ACRP30,APM1,GBP28, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Adipocyte Complement-Related 30 kDa Protein is produced by our Mammalian expression system and the target gene encoding Glu19-Asn244 is expressed with a 6His tag at the C-terminus.Accession:Q15848. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:25.58 KDa. Background:Adiponectin is a secreted protein. It is synthesized exclusively by adipocytes and secreted into plasma. Adiponectin is an important adipokine that is involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Adiponectin Stimulates AMPK phosphorylation and activates in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Adiponectin also antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. It inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. Adiponectin may play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex: LMW, MMW or HMW.