Recombinant Human AKR1C3 (C-6His)

Description

EnkiLife provides the Recombinant Human AKR1C3 (C-6His) protein,aslo know as Aldo-Keto Reductase Family 1 Member C3,17-Beta-Hydroxysteroid Dehydrogenase Type 5,17-Beta-HSD 5,3-Alpha-HSD Type II Brain,3-Alpha-Hydroxysteroid Dehydrogenase Type 2,3-Alpha-HSD Type 2,Chlordecone Reductase Homolog HAKRb,Dihydrodiol Dehydrogenase 3,DD-3,DD3,Dihydrodiol Dehydrogenase Type I,HA1753,Indanol Dehydrogenase,Prostaglandin F Synthase,Testosterone 17-Beta-Dehydrogenase 5,Trans-1,2-Dihydrobenzene-1,2-Diol Dehydrogenase,AKR1C3,DDH1,HSD17B5,KIAA0119,PGFS, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Aldo-Keto Reductase Family 1 Member C3 is produced by our Mammalian expression system and the target gene encoding Met1-Tyr323 is expressed with a 6His tag at the C-terminus.Accession:P42330. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:37.9 KDa. Background:AKR1C3, is an enzyme which belongs to the aldo/keto reductase family. It is expressed in many tissues including adrenal gland, brain, kidney, liver, lung, mammary gland, placenta, small intestine, colon, spleen, prostate and testis. AKR1C3 catalyzes the conversion of aldehydes and ketones to alcohols. It catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2,which functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. It can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites.