Recombinant Human AKR1C4 (N-6His)

Description

EnkiLife provides the Recombinant Human AKR1C4 (N-6His) protein,aslo know as Aldo-Keto Reductase Family 1 Member C4,3-Alpha-HSD1,3-Alpha-Hydroxysteroid Dehydrogenase Type I,Chlordecone Reductase,CDR,Dihydrodiol Dehydrogenase 4,DD-4,DD4,HAKRA,AKR1C4,CHDR, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Aldo-Keto Reductase Family 1 Member C4 is produced by our E.coli expression system and the target gene encoding Met1-Tyr323 is expressed with a 6His tag at the N-terminus.Accession:P17516. Expression Host:E.coli.Species:Human.Predicted Molecular Mass:39.3 KDa. Background:Aldo-Keto Reductase 1C4/AKR1C4 is a member of the aldo/keto reductase family that consists of more than 40 known enzymes and proteins. AKR1C4 has highly expressed in Liver. It can catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. AKR1C4 catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-α-Androstan-3-α,17-β-diol (3-α-diol). In addition, AKR1C4 also has some 20-α-Hydroxysteroid Dehydrogenase activity.