Recombinant Human APE

Description

EnkiLife provides the Recombinant Human APE protein,aslo know as DNA-(Apurinic or Apyrimidinic Site) Lyase,APEX Nuclease,APEN,Apurinic-Apyrimidinic Endonuclease 1,AP Endonuclease 1,APE-1REF-1,Redox Factor-1,APEX1,APE,APE1,APEX,APX,HAP1,REF1, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Apurinic-Apyrimidinic Endonuclease 1 is produced by our E.coli expression system and the target gene encoding Pro2-Leu318 is expressed.Accession:AAH02338.1. Expression Host:E.coli.Species:Human.Predicted Molecular Mass:35.62 KDa. Background:Apurinic-Apyrimidinic Endonuclease 1 (APE1) is required for efficient DNA base excision repair. When the DNA glycosylase remove the damaged bases, APE1 cleaves the AP site to allow resynthesis and ligation to complete repair. APE1 stimulates the DNA binding activity of many transcription factors, which participate in cancer promotion and progression. APE1 regulates the redox state of multiple transcription factors, such as c-Jun, c-Fos, NF-kB, p53. APEN is also involved in calcium-dependent down-regulation of PTH expression.