Recombinant Human ASXL1 (N-GST)

Description

EnkiLife provides the Recombinant Human ASXL1 (N-GST) protein,aslo know as Putative Polycomb group protein ASXL1,Additional sex combs-like protein 1,ASXL1,KIAA0978;, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Additional Sex Combs-Like Protein 1 is produced by our E.coli expression system and the target gene encoding Lys1477-Arg1541 is expressed with a GST tag at the N-terminus.Accession:Q8IXJ9. Expression Host:E.coli.Species:Human.Predicted Molecular Mass:33.6 KDa. Background:Putative Polycomb group protein ASXL1 involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG). It acts as coactivator of RARA and RXRA through association with NCOA1. ASXL1 also acts as corepressor through recruitment of KDM1A and CBX5 to target genes in a cell-type specific manner; the function seems to involve differential recruitment of methylated histone H3 to respective promoters.