Recombinant Human B-cell Activating Factor (TNFSF13B) (E. coli)

Description

The B cell-activating factor from the TNF family BAFF , is emerging as an important regulator of B cell and T cell responses. BAFF was originally identified as a factor responsible for B cell survival and maturation. BAFF binds to several receptors. These include transmembrane activator and calcium modulator and cyclophilin ligand interactor TACI , BAFF-R BR3 , and B cell maturation Ag BCMA . BAFF-R appears to be particularly important for the regulation of B cell survival and maturation in the spleen, because A/WySnJ mice expressing a defective BAFF-R have disrupted B cell maturation, similar to that seen in BAFF-deficient mice.