Recombinant Human B7-1 (C-mFc)

Description

EnkiLife provides the Recombinant Human B7-1 (C-mFc) protein,aslo know as CD80,Activation B7-1 antigen,B7,BB1,CD28LG1,CD28LGB7-1 antigen,T-lymphocyte activation antigen CD80, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Activation B7-1 Antigen is produced by our Mammalian expression system and the target gene encoding Val35-Leu242 is expressed with a mouse IgG1 Fc tag at the C-terminus.Accession:P33681. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:50.5 KDa. Background:Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily which plays key, yet distinct roles in the activation of T cells. It is the ligand for two different proteins on the T cell surface: CD28 and CTLA-4. Studies have shown that CTLA-4 binds mostly to CD80. The structure presents two extracellular domains: a membrane distal variable-like domain (IgV) and a membrane proximal Ig constant-like domain (IgC) along with an intracellular domain. Both IgV and IgC consist of anti-parallel beta sandwiches joined by a short linker region. CD80 is mostly expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells.