Recombinant Human Bcl-xL (C-6His)

Description

EnkiLife provides the Recombinant Human Bcl-xL (C-6His) protein,aslo know as Bcl-2-Like Protein 1,Bcl2-L-1,Apoptosis Regulator Bcl-X,BCL2L1,BCL2L,BCLX, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human B Cell Lymphoma/Leukemia x Long Form is produced by our E.coli expression system and the target gene encoding Met1-Arg212 is expressed with a 6His tag at the C-terminus.Accession:Q07817. Expression Host:E.coli.Species:Human.Predicted Molecular Mass:24.85 KDa. Background:Bcl-2-Like Protein 1 (BCL2L1) is a member of the Bcl-2 family. BCL2L1 is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. BCL2L1 is a mitochondrial membrane protein. BCL2L1 contains four motifs, BH1, BH2 and BH4. The BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl-2 family members and for repression of cell death. BCL2L1 regulates cell death by blocking the voltage-dependent anion channnel (VDAC) and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. In addition, BCL2L1 promotes apoptosis.