Recombinant Human BLNK (C-6His)

Description

EnkiLife provides the Recombinant Human BLNK (C-6His) protein,aslo know as B-Cell Linker Protein,B-Cell Adapter Containing a SH2 Domain Protein,B-Cell Adapter Containing a Src Homology 2 Domain Protein,Cytoplasmic Adapter Protein,Src Homology 2 Domain-Containing Leukocyte Protein of 65 kDa,SLP-65,BLNK,BASH,SLP65, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human B-Cell Linker Protein is produced by our E.coli expression system and the target gene encoding Met1-Ser456 is expressed with a 6His tag at the C-terminus.Accession:AAH18906. Expression Host:E.coli.Species:Human.Predicted Molecular Mass:51.5 KDa. Background:B-Cell Linker Protein (BLNK) is a cell membrane protein which contains 1 SH2 domain. BLNK is expressed in B cells and fibroblast cell lines, playing a important role in B cell receptor signaling. BLNK as a central linker protein, downstream of the B-cell receptor (BCR), bridges the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. BLNK associates with the activation of ERK/EPHB2, MAP kinase p38 and JNK, modulates AP1, NF-kappa-B and NFAT activation. BLNK involves in BCR-mediated PLCG1 and PLCG2 activation and Ca2+ mobilization and is required for trafficking of the BCR to late endosomes. BLNK deficiency results in agammaglobulinemia type 4 and much more profound block in B-cell development.