Recombinant Human BMPR1A (C-Fc-6His)

Description

EnkiLife provides the Recombinant Human BMPR1A (C-Fc-6His) protein,aslo know as Bone Morphogenetic Protein Receptor Type-1A,BMP Type-1A Receptor,BMPR-1A,Activin Receptor-Like Kinase 3,ALK-3,Serine/Threonine-Protein Kinase Receptor R5,SKR5,CD292,BMPR1A,ACVRLK3,ALK3, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Bone Morphogenetic Protein Receptor Type IA/Activin Receptor-like Kinase 3 is produced by our Mammalian expression system and the target gene encoding Gln24-Arg152 is expressed with a human IgG1 Fc, 6His tag at the C-terminus.Accession:P36894. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:42.1 KDa. Background:Bone Morphogenetic Protein Receptor Type-1A (BMPR1A) belongs to the TKL Ser/Thr protein kinase family and TGFB receptor subfamily, including the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. BMPR1A is a single-pass type I membrane protein and highly expressed in skeletal muscle. BMPR1A contains one GS domain and one protein protein kinase domain. BMPR1A is necessary for the extracellular matrix depostition by osteoblasts. BMPR1A can activate SMAD transcriptional regulators, binding with ligands. Defects in BMPR1A are a cause of juvenile polyposis syndrome, Cowden disease and hereditary mixed polyposis syndrome 2 (HMPS2).