Recombinant Human BMPR2 (C-6His)

Description

EnkiLife provides the Recombinant Human BMPR2 (C-6His) protein,aslo know as Bone Morphogenetic Protein Receptor Type-2,BMP Type-2 Receptor,BMPR-2,Bone Morphogenetic Protein Receptor Type II,BMP Type II Receptor,BMPR-II,BMPR2,PPH1, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Bone Morphogenetic Protein Receptor Type IIA is produced by our Mammalian expression system and the target gene encoding Ser27-Ile151 is expressed with a 6His tag at the C-terminus.Accession:Q13873. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:15.05 KDa. Background:Bone Morphogenetic Protein Receptor II (BMPR-II) is a Type II Serine/Threonine Kinase that mediates cellular responses to BMPs. BMPR-II is characterized by lacking of a GS domain, and presence of a C-terminal extension typical of type II receptors. BMPRII binds BMP2, BMP4 and BMP7 weakly in the absence of type I receptor, and the binding can be facilitated by the presence of the type I receptor, including BMPR-IA/Brk1, BMPR-IB, and ActR-I. BMPR-II plays a key role in cell growth. Defects in BMPR-II have been linked to primary pulmonary hypertension. Human and mouse BMPR-II are highly conserved and share 97 % amino acid sequence identity.