Recombinant Human C1QTNF1 (C-6His)

Description

EnkiLife provides the Recombinant Human C1QTNF1 (C-6His) protein,aslo know as Complement C1q Tumor Necrosis Factor-Related Protein 1,G Protein-Coupled Receptor-Interacting Protein,GIP,C1QTNF1,CTRP1, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Complement C1q and Tumor Necrosis Factor-Related Protein 1 is produced by our Mammalian expression system and the target gene encoding Arg26-Pro281 is expressed with a 6His tag at the C-terminus.Accession:Q9BXJ1. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:30.24 KDa. Background:C1QTNF1 is a secreted protein，contains 1 C1q domain and 1 collagen-like domain. C1qTNF proteins constitute a highly conserved family of Acrp30/Adiponectin paralogs that share a modular organization comprising an N-terminal signal peptide, a short variable region, a collagenous domain and a C-terminal globular domain. C1qTNF proteins are predicted to have trimeric structures that assemble into hexameric and higher order molecular forms. C1QTNF1 is a novel adipokine, providing a significant framework to further address the physiological functions and mechanisms of the action of this family of secreted glycoproteins in normal and disease states. C1QTNF1 increases the production of aldosterone. C1QTNF1 is vastly expressed in obese subjects as well as up-regulated in hypertensive patients, C1QTNF1 is identified molecular link between obesity and hypertension. C1QTNF1 expression may be associated with a low-grade chronic inflammation status in adipose tissues.