Recombinant Human CD147 (C-mFc)

Description

EnkiLife provides the Recombinant Human CD147 (C-mFc) protein,aslo know as Basigin,Basic immunoglobulin superfamily,HT7 antigen,Membrane glycoprotein gp42,CD147,Bsg, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Basigin is produced by our Mammalian expression system and the target gene encoding Ala22-His205 is expressed with a mouse IgG1 Fc tag at the C-terminus.Accession:P35613-2. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:46.5 KDa. Background:Basigin/CD147 is a member of the immunoglobulin superfamily with homology to both the immunoglobulin V domain and MHC class II antigen beta-chain. This protein play important roles in variety of events including spermatogenesis, embryo implantation, neural network formation. CD147 induces the production and release of matrix metalloproteinases (MMP) in the surrounding mesenchymal cells and tumor cells, and thereby promotes invasion, metastasis, growth and survival of malignant cells. Furthermore, CD147 also serves as a receptor for extracellular cyclophilinthe and its association with integrins might be important in signal transduction. CD147 displays increased expression in many cancers, and it has been previously demonstrated to participate in cancer metastasis and progression.