Recombinant Human CD161 (C-6His)

Description

EnkiLife provides the Recombinant Human CD161 (C-6His) protein,aslo know as Killer cell lectin-like receptor subfamily B member 1,KLRB1,CLEC5B,NKRP1A,CD161,Natural killer cell surface protein P1A,NKR-P1A,HNKR-P1a,C-type lectin domain family 5 member B,KLRB1, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Killer cell lectin-like receptor subfamily B member 1 is produced by our Mammalian expression system and the target gene encoding Gln67-Ser225 is expressed with a 6His tag at the C-terminus.Accession:AAI14517.1. Expression Host:Human cells.Species:Human.Predicted Molecular Mass:20.1 KDa. Background:Killer cell lectin-like receptor subfamily B, member 1(KLRB1) is a single-pass type II membrane protein which contains 1 C-type lectin domain. KLRB1 plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. It acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.