Recombinant Human CD30 (C-mFc)

Description

EnkiLife provides the Recombinant Human CD30 (C-mFc) protein,aslo know as Tumor necrosis factor receptor superfamily member 8,CD30L receptor,Ki-1 antigen,Lymphocyte activation antigen CD30,CD30,TNFRSF8, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Tumor necrosis factor receptor superfamily member 8 is produced by our Mammalian expression system and the target gene encoding Phe19-Lys379 is expressed with a mouse IgG1 Fc tag at the C-terminus.Accession:P28908. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:64.8 KDa. Background:CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family, which regulates proliferation/apoptosis and antibody responses. CD30 is expressed by activated, but not by resting, T and B cells. Aberrant expression of CD30 by mastocytosis mast cells and interaction with its ligand CD30L (CD153) appears to play an important role in the pathogenesis and clinical presentation of systemic mastocytosis. CD30 has been considered as a specific diagnostic biomarker of anaplastic large cell lymphoma (ALCL) and classical Hodgkin lymphoma (cHL). CD30 is also a biomarker used for targeted therapy by an antibody–drug conjugate.