Recombinant Human CD300a (C-Fc-6His)

Description

EnkiLife provides the Recombinant Human CD300a (C-Fc-6His) protein,aslo know as CMRF35-like molecule 8,CD300 antigen-like family member A,CMRF-35-H9,CMRF35-H,IRC1/IRC2,Immunoglobulin superfamily member 12,Inhibitory receptor protein 60,NK inhibitory receptor, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Leukocyte Mono-Ig-like Receptor 1 is produced by our Mammalian expression system and the target gene encoding Leu18-Gln178 is expressed with a human IgG1 Fc, 6His tag at the C-terminus.Accession:Q9UGN4. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:45.4 KDa. Background:CD300A is a single-pass type I membrane protein which belongs to the CD300 family. It contains 1 Ig-like V-type (immunoglobulin-like) domain. The CD300 family of myeloid immunoglobulin receptors includes activating (CD300b, CD300e) and inhibitory members (CD300a, CD300f), as well as molecules presenting a negative charge within their transmembrane domain (CD300c, CD300d). It is expressed not only by natural killer (NK) cells but also by T-cell subsets, B-cells, dendritic cells, mast cells, granulocytes and monocytes. CD300A is an inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. CD300c is a functional immune receptor able to deliver activating signals upon ligation in RBL-2H3 mast cells.