Recombinant Human CD40 (C-mFc)

Description

EnkiLife provides the Recombinant Human CD40 (C-mFc) protein,aslo know as Tumor Necrosis Factor Receptor Superfamily member 5,B-Cell Surface Antigen CD40,Bp50,CD40L Receptor,CDw40,CD40,TNFRSF5, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human CD40L Receptor is produced by our Mammalian expression system and the target gene encoding Glu21-Arg193 is expressed with a mouse IgG1 Fc tag at the C-terminus.Accession:P25942. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:45.7 KDa. Background:CD40 is a Type I Transmembrane Glycoprotein that belongs to the TNF Receptor Superfamily. CD40 is expressed in B cells, follicular dendritic cells, dendritic cells, activated monocytes, macrophages, endothelial cells, vascular smooth muscle cells, and several tumor cell lines. The extracellular domain of CD40 is characterized by Cysteine rich repeat regions. Interaction of CD40 with its ligand (CD40L) leads to aggregation of CD40 molecules, which in turn interact with cytoplasmic components to initiate signaling pathways. Several different TRAF proteins (adaptor proteins) have been identified to serves as mediators of the signal transduction. CD40 plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation.