Recombinant Human CD44 (C-6His)

Description

EnkiLife provides the Recombinant Human CD44 (C-6His) protein,aslo know as CD44 Antigen,CDw44,Epican,Extracellular Matrix Receptor III,ECMR-III,GP90 Lymphocyte Homing/Adhesion Receptor,HUTCH-I,Heparan Sulfate Proteoglycan,Hermes Antigen,Hyaluronate Receptor,Phagocytic Glycoprotein 1,PGP-1,Phagocytic Glycoprotein I,PGP-I,CD44,LHR,MDU2,MDU3,MIC4, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human CD44 is produced by our Mammalian expression system and the target gene encoding Gln21-Pro220 is expressed with a 6His tag at the C-terminus.Accession:P16070. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:23.1 KDa. Background:CD44 is a cell-surface receptor for hyaluronic acid and also interacts with other ligands, such as osteopontin, collagens, and matrix metalloproteinases. A large number of CD44 isoforms can be generated by the insertion of different combinations of at least nine exons. Increased CD44 antigen is associated with relapses in non-small cell lung cancers. Furthermore, an increasing quantity of evidence suggests that CD44 has various functions related to inflammatory disease. CD44 deficiency induces severe liver injury. CD44-hyaluronate mediates in lymphocyte T and monocyte adhesion to the endothelium, stimulates proinflammatory cytokine release from macrophages and participates in dedifferentiation phenotype of smooth muscle cells from contractile state to synthetic one.