Recombinant Human CD47 (C-mFc)

Description

EnkiLife provides the Recombinant Human CD47 (C-mFc) protein,aslo know as Leukocyte surface antigen CD47,Antigenic surface determinant protein OA3,Integrin-associated protein,IAP,Protein MER6,CD47,MER6, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Leukocyte Surface Antigen CD47 is produced by our Mammalian expression system and the target gene encoding Gln19-Pro139 is expressed with a mouse IgG1 Fc tag at the C-terminus.Accession:Q08722. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:40.3 KDa. Background:CD47(Integrin-Associated Protein,IAP) is a 40 ‑ 60 kDa variably glycosylated atypical member of the immunoglobulin superfamily. The ubiquitously expressed CD47 binds to SIRP family members on macrophages, neutrophils, and T cells. CD47 is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The protein is also a receptor for the C-terminal cell-binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This protein has broad tissue distribution, and is reduced in expression on Rh erythrocytes.