Recombinant Human CD58 (C-6His)

Description

EnkiLife provides the Recombinant Human CD58 (C-6His) protein,aslo know as Lymphocyte Function-Associated Antigen 3,Surface Glycoprotein LFA-3,CD58,LFA3,Ag3,CD58 antigen, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Lymphocyte Function-associated Antigen 3 is produced by our Mammalian expression system and the target gene encoding Phe29-Arg215 is expressed with a 6His tag at the C-terminus.Accession:AAH05930. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:22.5 KDa. Background:Lymphocyte function-associated antigen 3 (LFA-3/CD58) is a single-pass type I membrane protein. CD58 is widely expressed on hematopoietic and non-hematopoietic human tissue and has been found on leukocytes, erythrocytes, endothelial cells, epithelial cells and fibroblasts of human origin. It is a Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells.