Recombinant Human CD68 (C-Fc)

Description

EnkiLife provides the Recombinant Human CD68 (C-Fc) protein,aslo know as CD68 antigenmacrophage antigen CD68,CD68 molecule,CD68,gp110,Macrosialin,SCARD1,SRD1,SR-D1, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Macrosialin is produced by our Mammalian expression system and the target gene encoding Asn22-Ile320 is expressed with a human IgG1 Fc tag at the C-terminus.Accession:P34810. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:58.5 KDa. Background:CD68, also called Scavenger Receptor D1 (SR-D1) and LAMP-4, is a heavily glycosylated type I transmembrane glycoprotein that belongs to the LAMP family. CD68 is expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites. CD68 plays a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. It is a commonly used marker for macrophages. CD68 is also a biomarker of rheumatoid arthritis and Hodgkins lymphoma. CD68 influences the functions of cells through NF-kB/focal adhesion kinase pathway (7). In addition, CD68 on macrophages binds tightly to both S100A8 and S100A9 to enhance the cell immunity.