Recombinant Human CD82 (N-Fc)

Description

EnkiLife provides the Recombinant Human CD82 (N-Fc) protein,aslo know as CD82 antigenC33,CD82 molecule,CD82,IA4,IA4C33 antigen,Inducible membrane protein R2,KAI1,KAI1GR15,ST6,ST6tspan-27,Suppressor of tumorigenicity 6 protein,Tetraspanin-27,TSPAN27,Tspan-27,TSPAN274F9, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human CD82 Antigen is produced by our Mammalian expression system and the target gene encoding Gly103-Gln225 is expressed with a human IgG1 Fc tag at the N-terminus.Accession:P27701. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:40.3 KDa. Background:CD82 antigen, also known as Kai-1, is a widely expressed palmitoylated molecule of the tetraspanin superfamily. KAI1/CD82 is localized on cell membrane and form interactions with other tetraspanins, integrins and chemokines which are respectively responsible for cell migration, adhesion and signaling. CD82/Kai-1 is a component of the promiscuous TIMP-1 interacting protein complex on the cell surface of human adenocarcinoma cells and gives insight into tumorigenic metastatic potential. CD82/Kai-1 suppresses EMT in prostate cancer cells adhered to fibronectin leading to reduced cell migration and invasiveness. CD82/Kai-1 function is important for muscle stem cell function in muscular disorders. Overexpression of CD82/Kai-1 suppresses growth, migration and invasion of oral cancer cells and may be considered as a potential therapeutic target in oral cancer.