Recombinant Human CD98 (N-mFc)

Description

EnkiLife provides the Recombinant Human CD98 (N-mFc) protein,aslo know as 4F2 cell-surface antigen heavy chain,4F2hc,SLC3A2,Lymphocyte activation antigen 4F2 large subunit,Solute carrier family 3 member 2,MDU1,CD98, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human 4F2 Cell-surface Antigen Heavy Chain is produced by our Mammalian expression system and the target gene encoding Arg206-Ala630 is expressed with a mFc tag at the N-terminus.Accession:P08195. Expression Host:Human cells.Species:Human.Predicted Molecular Mass:72.7 KDa. Background:CD98 is a multifunctional glycoprotein that is involved in various biological processes such as amino acid transport, cell adhesion, diffusion, adhesion, and proliferation. CD98 can interact with CD147 to induce integrin 1 function to promote cyclosporine B-induced cell adhesion and p44/p42 MAPK activation following PI3K activation. CD98 heavy chain has been studied to be a key player in tumorigenesis due to its role in activating integrin signaling to promote tumor progression via angiogenesis, invasiveness, and proliferation in addition to promoting malignant transformation of cells. Fibrotic progression in the liver could be linked to the activation of integrin αvβ1 via CD98. CD98’s role in T cell activation in which the TGF activation could also play a profibrotic role.