Recombinant Human CDKN2C (N-6His)

Description

EnkiLife provides the Recombinant Human CDKN2C (N-6His) protein,aslo know as Cyclin-Dependent Kinase 4 Inhibitor C,Cyclin-Dependent Kinase 6 Inhibitor,p18-INK4c,p18-INK6,CDKN2C,CDKN6, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Cyclin-Dependent Kinase 4 Inhibitor C is produced by our E.coli expression system and the target gene encoding Met1-Gln168 is expressed with a 6His tag at the N-terminus.Accession:P42773. Expression Host:E.coli.Species:Human.Predicted Molecular Mass:20.3 KDa. Background:Cyclin-Dependent Kinase 4 Inhibitor C (CDKN2C) is a member of the INK4 family of cyclin dependent kinase inhibitors. CDKN2C contains 4 ANK repeats and interacts with CDK4 or CDK6. Highest levels of CDKN2C can be found in skeletal muscle, pancreas, and heart. CDKN2C inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB and prevent the activation of the CDK kinases. Studies have been shown the roles of CDKN2C gene in regulating spermatogenesis, as well as in suppressing tumorigenesis.