Recombinant Human CES1 (C-6His)

Description

EnkiLife provides the Recombinant Human CES1 (C-6His) protein,aslo know as Liver Carboxylesterase 1,Acyl-Coenzyme A:Cholesterol Acyltransferase,ACAT,Brain Carboxylesterase hBr1,Carboxylesterase 1,CE-1,hCE-1,Cocaine Carboxylesterase,Egasyn,HMSE,Methylumbelliferyl-Acetate Deacetylase 1,Monocyte/Macrophage Serine Esterase,Retinyl Ester Hydrolase,REH,Serine Esterase 1,Triacylglycerol Hydrolase,TGH,CES1,CES2,SES1, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Carboxylesterase 1 is produced by our Mammalian expression system and the target gene encoding His19-Glu562 is expressed with a 6His tag at the C-terminus.Accession:P23141-3. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:61.05 KDa. Background:Carboxylesterase 1 (CES1) is a member of a large family of carboxylesterases that are responsible for the hydrolysis of ester and amide bonds. These enzymes have broad substrate specificity ranging from small molecule esters such as phenylester to long chain fatty acid esters and thioesters. They are major determinants of the pharmacokinetic behavior of most therapeutic agents containing an ester or amide bond. CES1 shares the serine hydrolase fold observed in other esterases. CES1 hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. CES1 participates in detoxification of drugs such as cocaine and heroin in serum and liver. It may also play a role in detoxification in the lung and/or protection of the central nervous system from ester or amide compounds.