Recombinant Human CFHR1 (C-6His)

Description

EnkiLife provides the Recombinant Human CFHR1 (C-6His) protein,aslo know as Complement Factor H-Related Protein 1,FHR-1,H Factor-Like Protein 1,H-Factor-Like 1,H36,CFHR1,CFHL,CFHL1,CFHL1P,CFHR1P,FHR1,HFL1,HFL2, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Complement Factor H-Related 1 is produced by our Mammalian expression system and the target gene encoding Glu19-Arg330 is expressed with a 6His tag at the C-terminus.Accession:Q03591. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:36.78 KDa. Background:Complement Factor H-Related 1 (CFHR1) is a 43 kDa secreted member of the factor H family of glycoproteins. The human Complement Factor H protein family consists of the complement and immune regulators factor H, the factor H-like protein 1 (FHL-1) and five factor H-related proteins (CFHR-1 to -5). Members of the H-related protein family are exclusively composed of individually folded protein domains, termed short consensus repeats (SCRs) or complement control modules. FHR1 is produced by hepatocytes and circulates as two differentially glycosylated isoforms (37 kDa and 43 kDa). Mature human FHR1 is 312 amino acids in length. It contains five, approximately 60 aa SCRs that basically constitute the entire molecule. FHR1 may play a role in complement regulation, lipid metabolism and lipoprotein complexes that bind PMNs to LPS.