Recombinant Human CHI3L1 (C-6His)

Description

EnkiLife provides the Recombinant Human CHI3L1 (C-6His) protein,aslo know as Chitinase-3-Like protein 1,39 kDa Synovial Protein,Cartilage Glycoprotein 39,CGP-39,GP-39,hCGP-39,YKL-40,CHI3L1, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Chitinase-3-Like Protein 1 is produced by our Mammalian expression system and the target gene encoding Tyr22-Thr383 is expressed with a 6His tag at the C-terminus.Accession:P36222. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:41.5 KDa. Background:Chitinase-3-Like Protein 1 (CHI3L1) belongs to the glycosyl hydrolase 18 family. CHI3L1 is expressed in activated macrophages, articular chondrocytes, synovial cells as well as in liver. It lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. CHI3L1 is thought to play a role in defense against pathogens, or in tissue remodeling, and in the capacity of cells to respond to and cope with changes in their environment. In addition, CHI3L1 is associated with susceptibility to asthma-related traits type 7 (ASRT7) which assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis.