Recombinant Human Cornulin (N-6His)

Description

EnkiLife provides the Recombinant Human Cornulin (N-6His) protein,aslo know as Cornulin,53 kDa Putative Calcium-Binding Protein,53 kDa Squamous Epithelial-Induced Stress Protein,58 kDa Heat Shock Protein,Squamous Epithelial Heat Shock Protein 53,Tumor-Related Protein,CRNN,C1orf10,DRC1,PDRC1,SEP53, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Cornulin is produced by our E.coli expression system and the target gene encoding Met1-Ser140 is expressed with a 6His tag at the N-terminus.Accession:Q9UBG3. Expression Host:E.coli.Species:Human.Predicted Molecular Mass:17.45 KDa. Background:Cornulin is a member of the fused gene family of molecular chaperones. Human Cornulin contains N-terminus EF-hand domains and Ca2+ binding domains, and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. Cornulin involves in the mucosal/epithelial immune response and epidermal differentiation. Cornulin is a survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When Cornulin is overexpressed in oral squamous carcinoma cell lines, it regulates negatively cell proliferation by the induction of G1 arrest.