Recombinant Human CPE (C-6His)

Description

EnkiLife provides the Recombinant Human CPE (C-6His) protein,aslo know as Carboxypeptidase E(CPE for short),Carboxypeptidase H,Enkephalin convertase,Prohormone-processing carboxypeptidase, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Carboxypeptidase E is produced by our Mammalian expression system and the target gene encoding Arg42-Ser453 is expressed with a 6His tag at the C-terminus.Accession:P16870. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:47.2 KDa. Background:The active form of CPE cleaves C-terminal amino acid residues of the peptide, and is thus involved in the biosynthesis of peptide hormones and neurotransmitters including insulin, enkephalin, etc. It is thought that membrane-associated CPE acts as a sorting receptor for targeting regulated secretory proteins which are mostly prohormones and neuropeptides in the trans-Golgi network of the pituitary and in secretory granules into the secretory pathway. Defects in this protein are implicated in type II diabetes due to impaired glucose clearance and insulin resistance.