Recombinant Human CREG (C-6His)

Description

EnkiLife provides the Recombinant Human CREG (C-6His) protein,aslo know as CREG1,cellular repressor of E1A-stimulated genes,cellular repressor of E1A-stimulated genes 1CREG,protein CREG1, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Cellular Repressor Of E1A-stimulated Genes 1 is produced by our Mammalian expression system and the target gene encoding Arg32-Gln220 is expressed with a 6His tag at the C-terminus.Accession:O75629. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:21.9 KDa. Background:Cellular repressor of E1A genes (CREG) is an evolutionarily conserved lysosomal protein, and an important new factor in regulating tissue homeostasis that has been shown to antagonize injury of tissues or cells. CREG contains three mannose 6-phosphate (M6P) markers, and depends on interactions with M6P receptors for efficient delivery to lysosomes, which is implicated in the regulation of lysosomal functions. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. CREG plays an important role in the control of cell growth and differentiation. It has been shown that CREG antagonizes transcriptional and cellular transformation by the adenoviral E1A oncoprotein, induces differentiation while attenuating cellular proliferation, regulates the levels of the signaling kinases ERK1/2, and mediates glucocorticoid-induced proliferation of ileal epithelial cells. CREG is widely expressed in adult tissues, such as the brain, heart, lungs, liver, intestines and kidneys in mice, but is not markedly expressed in pluripotent embryonic stem cells.