Recombinant Human CRHBP (C-6His)

Description

EnkiLife provides the Recombinant Human CRHBP (C-6His) protein,aslo know as Corticotropin-Releasing Factor-Binding Protein,CRF-BP,CRF-Binding Protein,Corticotropin-Releasing Hormone-Binding Protein,CRH-BP,CRHBP,CRFBP, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Corticotropin-Releasing Factor-Binding Protein is produced by our Mammalian expression system and the target gene encoding Tyr25-Leu322 is expressed with a 6His tag at the C-terminus.Accession:P24387. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:34.38 KDa. Background:Corticotropin-Releasing Factor-Binding Protein (CRHBP) is a 37 kDa secreted glycoprotein that binds both CRH and urocortin in a 42 kDa extracellular complex. The molecule is approximately 300 amino acids in length and demonstrates five intrachain disulfide bonds. Difference between CRHBP from different species exist, human CRHBP is found in plasma while rodent and sheep CRHBP is limited to neuroendocrine tissues. CRHBP may inactivate CRH and may prevent inappropriate pituitary-adrenal stimulation in pregnancy. CRHBP is presumed to either sequester CRH, rendering it unavailable to cells or transport it to target tissues. Although CRF-BP concentration in the human peripheral circulation is normally low, it increases throughout pregnancy and fall back rapidly after parturition.