Recombinant Human CRT2

Description

EnkiLife provides the Recombinant Human CRT2 protein,aslo know as Calreticulin-3,calreticulin-2,calsperin,CALR3,CRT2, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Calreticulin-3 is produced by our E.coli expression system and the target gene encoding Thr20-Leu384 is expressed.Accession:Q96L12. Expression Host:E.coli.Species:Human.Predicted Molecular Mass:42.9 KDa. Background:Calreticulin-3 belongs to the calreticulin family, members of which are calcium binding chaperones localized mainly in the endoplasmic reticulum. It can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. During spermatogenesis process, Calreticulin-3 may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Defects in CALR3 are the cause of familial hypertrophic cardiomyopathy type 19 (CMH19), it is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain.