Recombinant Human Cyclophilin A (C-6His)

Description

EnkiLife provides the Recombinant Human Cyclophilin A (C-6His) protein,aslo know as Peptidyl-prolyl cis-trans isomerase A,PPIA,PPIase A,Cyclosporin A-binding protein,Rotamase A,Cyclophilin A,Cyclosporin A-binding protein,CYPA, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Peptidyl-prolyl cis-trans isomerase A is produced by our E.coli expression system and the target gene encoding Val2-Glu165 is expressed with a 6His tag at the C-terminus.Accession:P62937. Expression Host:E.coli.Species:Human.Predicted Molecular Mass:18.8 KDa. Background:Cyclophilin A, also known as peptidylprolyl isomerase A (PPIA), is an 18 kDa protein that catalyzes cis-trans isomerization at proline imidic peptide bonds, thereby promoting protein folding/trafficking and regulating protein activity. Cyclophilin A has multiple known functions in inflammation. Intracellularly, cyclophilin A interacts with interleukin (IL)-2 inducible T cell kinase (ITK) to tune T cell receptor signaling. Extracellularly, cyclophilin A is known to function as a leukocyte chemotactic factor. Cells secrete cyclophilin A by a vesicular secretory pathway in response to lipopolysaccharide and oxidative stress, or cyclophilin A may be released during cell death. Cyclophilin A influences inflammatory responses through its actions on immune activation and/or leukocyte trafficking.