Recombinant Human DCUN1D1 (N-6His)

Description

EnkiLife provides the Recombinant Human DCUN1D1 (N-6His) protein,aslo know as DCN1-Like Protein 1,DCUN1 Domain-Containing Protein 1,Defective in Cullin Neddylation Protein 1-Like Protein 1,Squamous Cell Carcinoma-Related Oncogene,DCUN1D1,DCUN1L1,RP42,SCCRO, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human DCN1-Like Protein 1 is produced by our E.coli expression system and the target gene encoding Met1-Val259 is expressed with a 6His tag at the N-terminus.Accession:Q96GG9. Expression Host:E.coli.Species:Human.Predicted Molecular Mass:32.3 KDa. Background:DCN1-Like Protein 1 is a protein containing 1 DCUN1 domain and 1 UBA-like domain. DCN1-Like Protein 1 contains part of an E3 Ubiquitin Ligase Complex for Neddylation. It is required for Neddylation of Cullin components of E3 Cullin-RING Ubiquitin Ligase complexes. It enhances the rate of Cullins Neddylation. DCN1-Like Protein 1 recruits the NEDD8-charged E2 Enzyme to the Cullin component. DCUN1D1 is involved in the release of inhibitory effects of CAND1 on the Cullin-RING Ligase E3 complex assembly and activity. It acts also as an oncogene facilitating malignant transformation and carcinogenic progression.