Recombinant Human DFF45 (N-6His)

Description

EnkiLife provides the Recombinant Human DFF45 (N-6His) protein,aslo know as DNA Fragmentation Factor Subunit Alpha,DNA Fragmentation Factor 45 kDa Subunit,DFF-45,Inhibitor of CAD,ICAD,DFFA,DFF1,DFF45,H13, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human DNA Fragmentation Factor Subunit Alpha is produced by our E.coli expression system and the target gene encoding Met1-Thr331 is expressed with a 6His tag at the N-terminus.Accession:AAH07721.1. Expression Host:E.coli.Species:Human.Predicted Molecular Mass:38.7 KDa. Background:DNA Fragmentation Factor Subunit Alpha (DFFA). DFFA exists as a heterodimer (DFF) with DFFB. DFF is activated once DFFA is cleaved by Caspase-3. The cleaved fragments of DFFA detach from DFFB (the active component of DFF), which in turn triggers DNA fragmentation as well as chromatin condensation during apoptosis. A reduced level of DFFA detected in ovarian endometriosis may be a part of an apoptosis-resistant mechanism enhancing the disease progression.