Recombinant Human DLL3 (C-6His)

Description

EnkiLife provides the Recombinant Human DLL3 (C-6His) protein,aslo know as Delta-like protein 3,Drosophila Delta homolog 3,Delta3,DLL3, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Delta-like protein 3 is produced by our Mammalian expression system and the target gene encoding Ala27-Leu492 is expressed with a 6His tag at the C-terminus.Accession:Q9NYJ7. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:49.4 KDa. Background:Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. DLL3 is highly expressed in tumor cells and could be involved in the modification of tumor (immune) microenvironment. Neuroendocrine carcinomas are very aggressive tumors with few treatment options. DLL3 seems to be an optimal target for therapeutic intervention, as it is expressed mainly on the membrane of tumor cells with neuroendocrine origin.