Recombinant Human Dtk (C-6His)

Description

EnkiLife provides the Recombinant Human Dtk (C-6His) protein,aslo know as Tyrosine-protein kinase receptor TYRO3,Tyrosine-protein kinase BYK,Tyrosine-protein kinase DTK,Tyrosine-protein kinase RSE,Tyrosine-protein kinase SKY,Tyrosine-protein kinase TIF,TYRO3,BYK,DTK,RSE,SKY,TIF, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Tyrosine-protein Kinase Receptor TYRO3 is produced by our Mammalian expression system and the target gene encoding Ala41-Ser428 is expressed with a 6His tag at the C-terminus.Accession:Q06418. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:42.4 KDa. Background:Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken cEyk)constitute a new receptor tyrosine kinase subfamily. The extracellular domain of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. All three receptors bind the vitamin K-dependent protein growth-arrest specific gene 6 (Gas6) which is structurally related to the anticoagulation factor protein S. The binding affinities for Gas6 is in the order of Axl //u003E Dtk //u003E Mer. Gas6 binding induces tyrosine phosphorylation and downstream signaling pathways that can lead to cell proliferation, migration, or the prevention of apoptosis. Dtk is widely expressed during embryonic development. In adults, Dtk is predominantly expressed in neurons in restricted regions of the brain.